汪泉

作者: 审核人: 访问量:4127发布时间:2018-09-06

 

姓名:汪泉性别:职务:
职称:教授导师类别:博士生导师办公室:伟德国际手机19462号楼404
研究领域:

1. 单细胞测序,空间转录组测序数据分析与处理;

2. 人类复杂疾病的遗传学机理;

3. 基于大数据挖掘的药物重定位。

电话:
Email:wangquan@nuaa.edu.cn
个人简介

   汪泉,博士,伟德国际手机1946教授,博士生导师,国家级重大人才工程A类青年项目入选者。2002年至2012年在北京大学学习,获北京大学理学博士学位,后在美国范德堡大学从事生物信息学研究工作十余年。目前研究方向为人类复杂疾病的生物信息处理与分析,基于多组学数据融合构建统计模型,解释复杂疾病的遗传学机理,发掘有重定向潜力的药物。在Nature Neuroscience, Molecular Psychiatry, Genome Biology, Bioinformatics等期刊发表论文27篇,引用超1500次,H index为16,研究成果引起新华网、福克斯新闻等知名大众媒体的广泛关注。受邀担任Briefings in Bioinformatics, Human Genetics, Bioinformatics等多个国际学术期刊审稿人。 


学术成果(1=共同第一作者)

1.Fang J1, Zhang P1, Wang Q1, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz JB, Pieper AA, Li B, 

 Li L, Cummings J, Cheng F. Artificial intelligence framework identifies candidate targets for drug repurposing in 

 Alzheimer’s disease. Alzheimer's research & therapy, 14(1):1-23, 2022


2.Yang H, Chen R, Wang Q, Wei Q, Ji Y, Zhong X, Li B. TVAR: assessing tissue-specific functional effects of non-coding

 variants with deep learning. Bioinformatics, 38(20):4697-4704, 2022


3.Wang Q1, Chen R1, Cheng F, Wei Q, Ji Y, Yang H, Zhong X, Tao R, Wen Z, Sutcliffe JS, Liu C, Cook EH, Cox NJ, Li B. 

 A Bayesian framework that integrates multi-omics data and gene networks predicts risk  genes from schizophrenia GWAS 

 data. Nature Neuroscience, 22(5):691-699, 2019


4.Patton SM, Wang Q, Hulgan T, Connor JR, Jia P, Zhao Z, Letendre SL, Ellis RJ, Bush WS, Samuels DC,  Franklin DR, 

 Kaur H, Iudicello J, Grant I, Kallianpur AR. Cerebrospinal fluid (CSF) biomarkers of iron  status are associated 

 with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults. Fluids and Barriers 

 of the CNS, 14(1):11, 2017


5.Wang Q, Yu H, Zhao Z, Jia P. EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and

 gene expression profiles. Bioinformatics, 31(15):2591-2594, 2015


6.Wang Q, Jia P, Cheng F, Zhao Z. Heterogeneous DNA methylation contributes to tumorigenesis through inducing the loss

 of co-expression connectivity in colorectal cancer. Genes, Chromosomes and Cancer, 54(2):110-121, 2015


7.Zhao Z, Xu J, Chen J, Kim S, Reimers M, Bacanu SA, Yu H, Liu C, Sun J, Wang Q, Jia P, Xu F, Zhang Y, Kendler KS, Peng Z,

 Chen X (2014). Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin 

 cytoskeleton remodeling in schizophrenia and bipolar disorder. Molecular Psychiatry, 20(5):563-572, 2015


8.Jia P, Wang Q, Chen Q, Hutchinson K, Pao W, Zhao Z. MSEA: detection and quantification of mutation hotspots through

 mutation set enrichment analysis. Genome Biology, 15(10):489, 2014


9.Wang Q, Peng P, Qian M, Wan L, Deng M. Hybridization and amplification rate correction for Affymetrix SNP arrays.

 BMC medical genomics, 5(24), 2012.


10.Wang Q, Wan L, Li D, Zhu L, Qian M, Deng M. Searching for bidirectional promoters in Arabidopsis thaliana. BMC 

 Bioinformatics, 10(Suppl 1):S29, 2009.




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